Just my thoughts on this in form of an answer, since the comment section got a little bit crowded. Feel free to not upvote this answer since there is no final conclusion from my side...
To estimate what to expect from a hands free input device, you have to realize: Our hands are very good a manipulating objects since we are trained to do so. So if you use anything other than a thing held in your hand, or a surface you touch with your fingers you may have to train for a longer time, or will not get the same precision and quickness. We are amazed by paintings made by foot for a reason: Painting with your feet is hard for the untrained person (and for me also with my hand, but thats another story :3).
You listed RSI as a reason for not using a mouse. IMO you will have a hard time replacing your mouse with a hands free version, so you might want to replace it with a more ergonomic version (same applies to the keyboard). Currently, I think hands free devices are limited to more simple, often used applications. For example I saw a setup (vimclutch) with a single foot pedal which implemented a "insert while pressed"-mode in vim (note: vim is a text editor on unix system, which normally uses keyboard shortcuts to toggle between command and edit modes). Other applications I could think of are again foot switches to switch between screens or applications, or to scroll webpages.